Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis
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چکیده
منابع مشابه
In Vitro Activity of Mefloquine and its Enantiomers Against Plasmodium falciparum
The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...
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BACKGROUND Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The antimalarial drug mefloquine shows antischistosomal activity in animal models and clinical trials, which calls for further investigations. METHODOLOGY We comparatively assessed the efficacy and tole...
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corresponding authors: Andrew Hemphill, Arunasalam Naguleswaran Institute of Parasitology, Vetsuisse Faculty, University of Berne Länggass-Strasse 122 CH-3012 Berne, Switzerland Phone +41 31 6312384 Fax +41 31 6312477 Email [email protected] [email protected] AC CE PT ED Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimic...
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Malaria is a serious public health problem. More than 100 tropical and sub-tropical countries are endemic for malaria. Pregnant women and children are the most sensitive to this disease and more than 750 000 people die of malaria each year. Among the five species of Plasmodium, P. falciparum is the parasite responsible for the most serious form of the disease and it has developed varying degree...
متن کاملPharmacokinetics of prophylactic mefloquine.
The pharmacokinetics of the prophylactic dose of mefloquine (Lariam: 500 mg every 4 weeks, with a loading dose of 750 mg on the first week) was studied in six healthy Thai male volunteers. Mefloquine was well tolerated during the study period of 16 weeks. The only side-effects found were nausea and diarrhea in 2 volunteers after the first dose of mefloquine. The mean minimum concentration of me...
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ژورنال
عنوان ژورنال: International Journal for Parasitology: Drugs and Drug Resistance
سال: 2018
ISSN: 2211-3207
DOI: 10.1016/j.ijpddr.2018.06.004